The monk Ramon Pane, who accompanied Columbus on his second trip to the Americas, in 1493, observed that the indigenous people of the region that now corresponds to Haiti, absorbed tobacco through a cane, and the same custom was observed by the Portuguese in the indigenous people of Brazil . By order of Felipe II, the doctor and botanist Francisco Hernández de Boncalo, was the one who introduced the first tobacco seeds to Europe in 1577, and were planted around Toledo . In 1561, the French ambassador in Lisbon, Jean Nicote, he sent rapé to Catherine de’ Medici, wife of King Henry II of France, as a medicinal treatment for her son’s migraine headaches . She fell in love with this powdered tobacco, and it became popular as both medicinal and recreational remedy among the elite . Soon it began to be consumed in Europe among the wealthiest groups, since tobacco, in all its formats, was then a luxury good. It was during the eighteenth century it became a completely widespread fashion among the European aristocracy. Smoking tobacco was destined for the masses, and the consumption of rapé became the largest customary and social ritual in Europe among bourgeois and aristocratic societies. At the beginning of the 20th century, in England, It was only smoked in lower-class bars , because the aristocrats could buy rapé, and they only consumed Rapé. So, little by little he became an inseparable ally of the nobility. Louis XIII, Charles II of England, Frederick the Great, William III and his wife, Napoleon, George III and his wife, Benedict XIII, and so many other aristocrats, were habitual rapé users.